Study on the Central Mechanism of Tuina in Treatment of Knee Osteoarthritis
- Conditions
- Knee Osteoarthritis
- Registration Number
- ITMCTR2100004799
- Lead Sponsor
- Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Comply with KOA's diagnostic criteria of Chinese and Western medicine, and meanwhile the syndrome differentiation of Chinese medicine is of Qi stagnation and blood stasis syndrome;
2. Aged 50 to 75 years, male or female, left knee pain, right handed;
3. The Kellgren-Lawrence radiology score is II-III;
4. Knee joint pain lasts for more than 6 months;
5. VAS score >= 3 points;
6. Occupation: non-manual workers (such as teachers, corporate office staff, etc.), no daily violent lower limb activities;
7. Agree and sign the informed consent form.
1. People with damaged skin around the knee joint;
2. History of knee surgery, history of severe trauma;
3. Patients with diabetes, systemic infections, severe liver and kidney function abnormalities, malignant tumors and other diseases;
4. Those who have received other treatment measures within the past month;
5. Those who are allergic to celecoxib capsules;
6. Pregnant or lactating women;
7. People with mental disorders or cognitive dysfunction;
8. Suffer from gastrointestinal system symptoms: such as active gastrointestinal ulcer/bleeding, or recurrent ulcer/bleeding;
9. People with MRI contraindications such as lock-in phobia, pacemaker, defibrillator, cardiac stent, intrauterine device, etc.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pressure Pain Thresholds;MRI scan to obtain various modal parameters;
- Secondary Outcome Measures
Name Time Method Hamilton Anxiety Scale;Pain Catastrophizing Scale;Numerical rating scale;Hamilton Depression Scale;