The effects of exogenous glucagon-like peptide-1 administration on glucose metabolism and gastric emptying in critically ill patients.

Phase 1

Completed

• Conditions: Critical illness; Metabolic and Endocrine - Other metabolic disorders

• Registration Number: ACTRN12608000562370
• Lead Sponsor: Royal Adelaide Hospital Intensive Care Unit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-11-07
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

critically ill patients and mechanically ventilated suitable for, or receiving, enteral nutrition and likely to stay ventilated for at least 48 hours.

Exclusion Criteria

Pregnancy, Contraindication to enteral nutrient administration, Previous surgery on the oesophagus, stomach or duodenum, Any gastrointestinal surgery on this hospital admission and History of diabetes mellitus

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
blood glucose concentration. Measured using bedside glucometer[0-6 hours];gastric emptying. Measured using scintigraphic and breath test techniques[0-8 hours];nutrient absorption. Measured using absorption of 3-O-Methyl-Glucose.[0-4 hours]

Secondary Outcome Measures

Name	Time	Method
Regulatory and counter-regulatory hormone release. Measured using plasma Insulin and glucagon concentrations[0-6 hours];plasma GLP-1 concentration[0-6 hours]