Role of Sympathetic Activation in Ischemia Reperfusion Injury
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- change in muscle sympathetic nerve activity
研究概览
简要总结
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote ischemic preconditioning. In addition it will assess whether pharmacologic inhibition of the sympathetic nervous system can ameliorate ischemia reperfusion injury induced endothelial dysfunction.
详细描述
This is a randomized single blind study where subjects will be allocated to undergo one of the 4 protocols. Participants will be given placebo or 0.2mg of Moxonidine to take orally 20 minutes prior to the first endothelial function measurement.
This medication acts by reducing the activity of nerves believed to be involved in the conditioning process. The placebo pill, designed to have no effect, will be used as a comparison. Comprehensive tests will occur which include Microneurography, Endothelial function ,Blood Sampling, Temporary block of arm blood flow and Remote conditioning
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy males, not on any medication, free of any history of metabolic, cardiovascular or cerebrovascular disease.
排除标准
- 未提供
研究组 & 干预措施
No conditioning + placebo
Participants will be given placebo to take orally 20 minutes prior to the first endothelial function measurement without conditioning tests.
干预措施: placebo (Other)
No conditioning + moxonidine
Participants will be given moxonidine to take orally 20 minutes prior to the first endothelial function measurement without conditioning tests.
干预措施: Moxonidine 0.2 MG (Drug)
Remote pre-conditioning + placebo
Participants will be given placebo to take orally 20 minutes prior to the first endothelial function measurement with conditioning tests.
干预措施: placebo (Other)
Remote pre-conditioning + moxonidine
Participants will be given moxonidine to take orally 20 minutes prior to the first endothelial function measurement with conditioning tests.
干预措施: Moxonidine 0.2 MG (Drug)
结局指标
主要结局
change in muscle sympathetic nerve activity
时间窗: 1 day
Muscle sympathetic nerve activity assessed by microneurography
次要结局
- Endothelial Function using the EndoPat2000 device(2 days)
研究者
Dr Markus Schlaich
Principal Investigator
Royal Perth Hospital