Effect of deep Transcranial Magnetic Stimulation in patients with OCD and itâ??s study using Functional Magnetic Resonance Imaging sca
Phase 3
- Conditions
- Health Condition 1: F422- Mixed obsessional thoughts and actsHealth Condition 2: F429- Obsessive-compulsive disorder, unspecifiedHealth Condition 3: F428- Other obsessive-compulsive disorder
- Registration Number
- CTRI/2020/07/026407
- Lead Sponsor
- Central Institute of Psychiatry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Diagnosis of Obsessive-Compulsive Disorder using Diagnostic Criteria for Research (DCR) of ICD 10 DCR (WHO, 1993)
2. Y-BOCS score of 15 or above
3. Age between 18-60 years of either sex
4. Right-handed
5. Educational qualification of class VIII and above
6. Patients giving written informed consent
Exclusion Criteria
1. Co-morbid severe depression as measured by a HAM-D score of 23 or more
2. Patients with co-morbid neurological or any other psychiatric disorder
3. Patients who cannot undergo MRI scan
4. Colour blind, as indicated by Ishiharaâ??s charts
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome of the study is the clinical improvement in patients with OCD as recorded on Y-BOCS scale as seen at the end of 2 weeks of high frequency dTMS treatment.Timepoint: 1. At baseline <br/ ><br>2. Day 1 (after 1st session of dTMS/sham stimulation ) <br/ ><br>3. Day 14 (at the end of 10 sessions of stimulation)
- Secondary Outcome Measures
Name Time Method Secondary outcomes are the changes in functional activation of ACC and mPFC as measured by resting state fMRI and Stroop task evoked fMRI following 10 session of high frequency dTMS in patients with OCD.Timepoint: 1. At baseline <br/ ><br>2. Day 1 (after 1st session of dTMS/Sham stimulation ) <br/ ><br>3. Day 14 (at the end of 10 sessions of stimulation )