Sedation and Postoperative Cognitive Functions

Completed

• Conditions: Cognitive Impairment; Femoral Fractures

• Registration Number: NCT05737459
• Lead Sponsor: Izmir Ataturk Training and Research Hospital

Brief Summary

Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. Patients who were given ketamine and dexmedetomidine for sedation were included in the study. The Mini Mental Status Tests of the patients measured on the first and third days of the operation in the preoperative period were determined from the hospital records and recorded.

Detailed Description

Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. The cognitive functions of these patients, which were evaluated by a Mini-Mental Test in the preoperative period, on the first and third days of surgery, were recorded from routine patient follow-up forms.

Sedation scores of the patients evaluated by Intraoperative Alertness/Sedation Scale (OAA/S) Observer Evaluation were recorded. Intraoperative hemodynamic data were recorded. The interventions applied to the patient were performed by anesthesiologists who were not involved in the study according to their preferences as part of the routine. The researchers were not involved in any intervention performed on the patient, only the data were recorded.

Study Timeline

• Study Start: 2022-05-01
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Status Verified: 2023-02
• Study First Submitted: 2023-02-02
• Study First Submitted QC: 2023-02-20
• Last Update Submitted: 2023-02-20
• Study First Posted: 2023-02-21
• Last Update Posted: 2023-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

• Patients over the age of 65 who underwent surgery under spinal anesthesia due to hip fracture
• Volunteered to participate in the study

Exclusion Criteria

• Patients who are under the age of 65
• Patients with known histories of dementia
• Patients with Alzheimer's disease
• Patients with central nervous system disease
• Patients who scored 15 or less according to the Mini Mental Status Test (MMSE)
• Patients who underwent surgery under general anesthesia
• Patients who refused to voluntarily participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mini-Mental Status Test	6 months	Evaluation of the effect of sedation with ketamine and dexmedetomidine on postoperative cognitive functions by Mini-Mental Status Test

Secondary Outcome Measures

Name	Time	Method
The heart rate	6 months	The effect of sedation on perioperative hemodynamics.
noninvasive mean arterial pressure	6 months	The effect of sedation on perioperative hemodynamics.

Trial Locations

Locations (1)

Izmir Katip Çelebi University Atatürk Training and Research Hospital; 🇹🇷 Izmir, Turkey