SingHEART: Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- First cardiovascular event
研究概览
简要总结
A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis. These findings will be correlated with adverse clinical outcomes including death, stroke and myocardial infarction. In selected cases, follow-up imaging and biomarker samples will also be obtained. These studies will enable us to begin to address a critical gap in our knowledge as to how best to interpret the very large amount of cardiovascular tests done in Singapore and how to better to predict outcomes and manage healthcare costs in our local populations
详细描述
SingHEART sub-study will collect the following data types or perform the following investigations:
- Demographic and clinical characteristics data.
- Basic blood investigations. Basic blood investigations include: FBC, CRP, renal panel, random glucose, LFT, fasting lipids, ESR, CRP,
- Perform a single baseline cardiac MRI (already consented and obtained as part of the primary study).
- ECG
- Calcium score
- Biobanking (whole blood, plasma and serum, already performed as part of the primary study)
- Exercise and physical activity tracker over two 1-week periods
- Ambulatory BP monitoring over two 24-48H periods
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women age 21-69 years
排除标准
- •Previous myocardial infarction (MI). This will include ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI)
- •Known coronary artery disease - prior coronary revascularization
- •Known documented peripheral arterial disease
- •Previous stroke
- •a. Stroke is defined as new focal neurological deficit persisting more than 24hours
- •More than ongoing use of 2 or more anti-hypertensive agents
- •Prior history of cancer (excludes pre-cancerous lesions)
- •Expected life expectancy less than 1 year
- •Known definite diabetes mellitus or on treatment for diabetes mellitus
- •Known autoimmune disease or genetic disease
- •Known endocrine disease on treatment
- •Psychiatric illness
- •Asthma or chronic lung disease requiring long term medications or oxygen
- •Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV
- •Inability to comply with study protocol
- •Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes
结局指标
主要结局
First cardiovascular event
时间窗: 1 year
次要结局
未报告次要终点