Effect of Huatuo Zaizao Pill on carotid atherosclerosis in patients with ischemic stroke

Phase 4

• Conditions: cerebral arterial thrombosis

• Registration Number: ITMCTR2100004606
• Lead Sponsor: Tianjin Medical University General Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1.Aged >= 35 and <= 75 years, regardless of gender;
2.Patients with ischemic stroke whose onset was <= 2 weeks (14d);
3.Carotid atherosclerosis with vulnerable plaque was diagnosed;
4.Signed the informed consent form and volunteered to participate in the clinical investigation.

Exclusion Criteria

1.Patients whose condition is serious enough to require surgery;
2.Coma patients (NIHSS 1a level of consciousness items > 1 point);
3.Liver dysfunction (alANINE aminotransferase or alanine aminotransferase exceeding 2 times of the upper limit of normal value), renal dysfunction (creatinine value exceeding 1.5 times of the upper limit of normal value);
4.The mentally ill;
5.Patients with intracranial hemorrhage confirmed by CT or MRI;
6.Participate in clinical trials of other medical facilities or drugs within 30 days of signing the informed consent;
7.Those who are allergic to the test drugs and their ingredients;
8.Pregnant women;
9.The researchers considered the participants unsuitable.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Carotid plaque Crouse score;

Secondary Outcome Measures

Name	Time	Method
lipoprotein-associated phospholipase A2;visual simulation score of headache severity;mRS;lipid levels;plaque area, plaque stability, carotid atherosclerotic inner membrane thickness;NIHSS;Hs-CRP;