Chronic stress level and functional health in older adults: the impact of fear of falling
Not Applicable
Recruiting
- Conditions
- fear of falling, sarcopenia
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Age of 70 years or older
- FES-I (16-item) score = 20
- Ability to come to the study center
without help
- Ability and willingness to provide
informed consent and accept
randomization to either study arm
Exclusion Criteria
- Life expectancy of less than 12 months
- Participation in another intervention trial (physical exercise or medical) at
the same time or within the previous 6 months
- Anti-inflammatory drugs (e.g. glucocorticoids, permanent prescribed NSAIDs)
- Cognitive impairment (Mini-Mental-Status-Examination [MMSE] < 24
points)
- Any medical, psychiatric, or behavioral factors that in the judgment of the
principal investigator may interfere with the study participation or the
ability to follow the intervention
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease in fall-related psychological concerns at T1 (after the intervention) by FES-I score in comparison to control group
- Secondary Outcome Measures
Name Time Method All secondary outcome meseaures will be assessed at all time points (T0, T1 and T2):<br>sarcopenia (BIA)<br>physical function (SPPB, handgrip strength)<br>health-related quality of life (EQ-5D+Vas)<br>physical activity (Actigraphy)<br>cognitive function (MMSE, TMT A+B)<br>general psychological status (GDS, PSS, GAS)<br>stress system activity (salivary cortsiol, alpha amylase)<br>systemic inflammation (CRP, IL-6, TNF-alpha, IL-10)<br>intracellular inflammatory activity (gene expression IL-1beta, IL-6, IL-10 and I-kappa B)<br>