Comparing Treatment out come of psoriasis with Oral Methotraxate versus Oral Tofacitinib
- Conditions
- Health Condition 1: L400- Psoriasis vulgaris
- Registration Number
- CTRI/2024/08/072427
- Lead Sponsor
- Rishana
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Chronic plaque psoriasis with PASI more than 10.
Patient with nail psoriasis.
Patient with Psoriatic arthritis.
Pregnancy and lactation.
Females and males who were planning to have a child and not willing for using contraception.
Systemic therapy taken for psoriasis in the past 4 weeks before enrolling into the study.
Topical therapy taken for psoriasis in past 2 weeks before enrolling into the study.
Acute or chronic liver disease or renal disease/ uncontrolled hypertension/ uncontrolled Diabetes mellitus.
known allergy to any of the study drugs.
Active infection such as Tuberculosis, HIV, Hepatitis B and C.
History of disseminated herpes zoster or herpes simplex or recurrent localized dermatomal herpes zoster.
Patient on any other immunosuppressants.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PASI50 <br/ ><br>PASI75 <br/ ><br>PASI90 <br/ ><br>NAPSI <br/ ><br>ACR20 <br/ ><br>ACR50 <br/ ><br>ACR70Timepoint: 0,4TH,8TH,12TH,16TH,20TH WEEK
- Secondary Outcome Measures
Name Time Method PATIENT SATISFACTION SCORE <br/ ><br>PHYSICIAN GLOBAL ASSESSMENT SCORETimepoint: 20TH WEEK