Differences in Cardiopulmonary Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition in Patients With Suspected Heart Failure With Preserved Ejection Fraction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Correlation of coronary blood flow with cardiopulmonary exercise capacity
研究概览
简要总结
The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.
详细描述
We will select the patients with chest pain or ischemic symptoms with non-obstructive coronary artery disease (<50% stenosis) in coronary angiography and preserved ejection fraction (≥50%) in echocardiography. All patients will undergo body composition analysis and adenosine stress echocardiography with the evaluation of coronary artery blood flow by Doppler echocardiography and maximal oxygen consumption (VO2 max) by cardiopulmonary exercise test (CPET). Left ventricular end-diastolic pressure will be assessed during coronary angiography. Coronary flow reserve (CFR) is defined as the ratio of peak to baseline mean diastolic velocity of coronary blood flow. The correlation of CFR and body composition with cardiopulmonary exercise capacity will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 20 to 80
- •Typical/atypical chest pain or ischemic symptoms including dyspnea
- •No significant coronary artery stenosis (>50% stenosis) in coronary angiography or computed tomography
- •Left ventricular ejection fraction ≥50%
排除标准
- •More than moderate valvular heart disease
- •Congenital heart disease
- •Chronic renal failure (estimated glomerular filtration rate <30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
- •Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
- •Receiving anticancer drugs
- •Vasculitis associated with autoimmune diseases
- •Patients with difficulty in performing exercise load evaluation (treadmill, bicycle ergometer)
- •Atrial fibrillation
- •Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients
结局指标
主要结局
Correlation of coronary blood flow with cardiopulmonary exercise capacity
时间窗: up to day 14
Coronary blood flow is assessed by coronary flow reserve (CFR), which is defined as peak to baseline mean diastolic velocity of coronary flow. In regard to cardiopulmonary exercise capacity, maximal oxygen consumption (VO2max) will be assessed.
Correlation of body composition with cardiopulmonary exercise capacity
时间窗: up to day 14
In body composition analysis, skeletal muscle mass and body fat mass will be assessed. In regard to cardiopulmonary exercise capacity, maximal oxygen consumption (VO2max) will be assessed.
次要结局
未报告次要终点
研究者
Seong-Mi Park, M.D. Ph.D.
Professor
Korea University Anam Hospital