Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFpEF)
- Interventions
- Diagnostic Test: Adenosine stress echocardiography with the evaluation of coronary artery blood flow
- Registration Number
- NCT04822649
- Lead Sponsor
- Korea University Anam Hospital
- Brief Summary
The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.
- Detailed Description
We will select the patients with chest pain or ischemic symptoms with non-obstructive coronary artery disease (\<50% stenosis) in coronary angiography and preserved ejection fraction (≥50%) in echocardiography. All patients will undergo body composition analysis and adenosine stress echocardiography with the evaluation of coronary artery blood flow by Doppler echocardiography and maximal oxygen consumption (VO2 max) by cardiopulmonary exercise test (CPET). Left ventricular end-diastolic pressure will be assessed during coronary angiography. Coronary flow reserve (CFR) is defined as the ratio of peak to baseline mean diastolic velocity of coronary blood flow. The correlation of CFR and body composition with cardiopulmonary exercise capacity will be assessed.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
- Age 20 to 80
- Typical/atypical chest pain or ischemic symptoms including dyspnea
- No significant coronary artery stenosis (>50% stenosis) in coronary angiography or computed tomography
- Left ventricular ejection fraction ≥50%
- More than moderate valvular heart disease
- Congenital heart disease
- Chronic renal failure (estimated glomerular filtration rate <30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
- Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
- Receiving anticancer drugs
- Vasculitis associated with autoimmune diseases
- Patients with difficulty in performing exercise load evaluation (treadmill, bicycle ergometer)
- Atrial fibrillation
- Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Heart failure with preserved ejection fraction Adenosine stress echocardiography with the evaluation of coronary artery blood flow Adenosine stress echocardiography, body composition, and cardiopulmonary exercise test will be done in all of the enrolled patients. Left ventricular end-diastolic pressure will be assessed during coronary angiography.
- Primary Outcome Measures
Name Time Method Correlation of coronary blood flow with cardiopulmonary exercise capacity up to day 14 Coronary blood flow is assessed by coronary flow reserve (CFR), which is defined as peak to baseline mean diastolic velocity of coronary flow.
In regard to cardiopulmonary exercise capacity, maximal oxygen consumption (VO2max) will be assessed.Correlation of body composition with cardiopulmonary exercise capacity up to day 14 In body composition analysis, skeletal muscle mass and body fat mass will be assessed.
In regard to cardiopulmonary exercise capacity, maximal oxygen consumption (VO2max) will be assessed.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of