Neural Mechanism of the Effect of Acupuncture on Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 160
- 试验地点
- 4
- 主要终点
- blood pressure
研究概览
简要总结
Based on previous published research in animals and human, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.
详细描述
The purpose of this study is to prove: (1) hypertensive response at rest and provoked by stress are decreased by EA; (2) The mechanisms of EA that reduces elevated blood pressure. EA inhibits the sympathetic nervous system, decreases blood pressure and reduces the oxygen demand. Our prior data in animals shows that improvements in cardiovascular function during myocardial ischemia, reflex hypertension and sustained hypertension are mediated by an EA-induced sensory neural reflex originating in somatic nerves to reduce sympathetic nerve activity. The specific aims of the present study will allow us to better understand and modulate the sympathetic nervous discharge activity that can cause hypertension during normal activity and stress in humans. The potential clinical application is the therapeutic value of EA in patients with hypertension.
Furthermore, the study will also investigate gender differences in the blood pressure lowering effect of EA. In particular in middle-aged hypertensive women and men.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
盲法说明
The care provider or acupuncturist does not know the outcome of the treatment. The investigator does not know the participants and the outcome of the study. The outcome assessor does not know the participants.
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with mild coronary disease, and no significant ECG change reflecting ischemia at rest.
- •Patients with high blood pressure with or without antihypertensive medication.
排除标准
- •Pregnant or nursing women
- •Individuals with severe coronary disease (continuous angina)
- •Conduction abnormalities on ECG consistent with left bundle branch block
- •Cardiac arrhythmias associated with low blood pressure (90 mmHg)
- •Peripheral vascular disease
- •Orthopedic disease
- •Diabetic or psychological illness that could interfere with safe performance of exercise of psychophysiological stress testing
- •Those with known sensitivity to topical preparations or strong reactions to medical dressings and skin tapes
结局指标
主要结局
blood pressure
时间窗: 8 weeks
evaluation of systolic and diastolic blood pressures changes
次要结局
- Heart rate(8 weeks)
- plasma catecholamine(8 weeks)
- plasma renin(8 weeks)
研究者
Shaista Malik
Professor
University of California, Irvine