Endometrial Injury and Single Embryo Transfer
Not Applicable
Completed
- Conditions
- Primary Infertility
- Interventions
- Device: Endometrial injury
- Registration Number
- NCT01851876
- Lead Sponsor
- Karadeniz Technical University
- Brief Summary
Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.
- Detailed Description
Endometrial injury means endometrial biopsy on day 3 of menstrual cycle following down regulation in an IVF patient.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 118
Inclusion Criteria
- woman age under 35 years
- history of primary infertility
- normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
- having grade I or II embryos for transfer
- agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.
Exclusion Criteria
- endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
- using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
- patients who did not proceed to follicle retrieval
- severe male infertility requiring TESA/TESA
- mullerian tract anomalies
- a history of endometrial instrumentation or surgery within a month of the study
- not agree to undergo endometrial biopsy during the COH cycle.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Endometrial injury Endometrial injury The patients in this group will be subjected to endometrial injury procedure in preceding IVF cycle.
- Primary Outcome Measures
Name Time Method Clinical Pregnancy Rate 4 months
- Secondary Outcome Measures
Name Time Method