itrous Oxide and Cerebral Autoregulatio

Conditions: This study is being conducted to evaluate the effects of inhaled concentrations of 20%, 30% and 40% Nitrous Oxide on cerebral autoregulation in healthy volunteers using transcranial doppler ultrasonography. This is part of a series of studies investigating the potential therapeutic use of low dose inhlaed nirous oxide in the treatment of cerebral vasospasm, ac condition which often occurs following traumatic brain in jury or stroke and can cause significant morbidity and mortality.

Registration Number: EUCTR2008-004669-24-GB

Lead Sponsor: Research Innovation Services, University of Nottingham

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

age between 18 and 50 years
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

those with history or evidence of systemic illness or vascular disease
those taking prescription medication which may affect the cardiovascular system
any evidence of neurological disorder
smoker
pregnant or lactating females

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: To evaluate the effects of inhaled nitrous oxide 20%, 30% and 40% on cerebral autoregulation.;Secondary Objective: To evaluate the effects of inhaled nitrous oxide 20%, 30% and 40% on cerebrovascular tone.;Primary end point(s): To discover the effect of inhalation of low dose Nitrous Oxide on cerebral autoregulation<br>primary outcomes<br>1.Transient Hyperaemic Response ratio at 20,30,40% inspired concentration of nitrous oxide<br>2.Strength of autoregulation at the 20,30,40 % inspired concentration of nitrous oxide<br>secondary outcomes<br>Middle Cerebral Artery blood flow velocity<br>ZFP (cerebral vascular tone)<br>heart rate, blood pressure, cardiac output, stroke volume, systemic vascular resistance<br>

Secondary Outcome Measures