Comparison of transpulmonary pressures by esophageal pressure measurement in supine and prone positions in patients with severe Acute Respiratory Distress Syndrome: An Observational Study

Sir Ganga Ram hospital0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•The study population includes patients equal to or more than 18 years of age admitted to the adult intensive careunit with severe ARDS (according to Berlin criteria) who are candidates for prone ventilationtherapy and have no contraindications for the placement of an oesophageal balloon catheter

•Contraindications to esophageal balloon placement
•Esophageal or nasopharyngeal pathology (such as tumors, sinusitis , epistaxis,ulcerations, recent surgery or bleeding varices) , Diverticulitis , Bronchopulmonary fistula ,Solid-organ transplantation , History of difficult intubation or airway management ,Duration of ARDS >=36 h or duration of mechanical ventilation >=96
•Contraindications to prone positioning
•Shock (eg, persistent mean arterial pressure <65 mmHg),Acute bleeding (eg, hemorrhagic shock, massive hemoptysis), Multiple fractures or trauma (eg, unstable fractures of femur, pelvis, face),Spinal instability, Pregnancy, Raised intracranial pressure >30 mmHg or cerebral perfusion pressure <60 mmHg, Tracheal surgery or sternotomy within two weeks

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