Comparison of change in pressure inside the lungs in patients with severe lung injury in supine and prone positions
- Conditions
- Health Condition 1: J22- Unspecified acute lower respiratory infection
- Registration Number
- CTRI/2021/02/031433
- Lead Sponsor
- Sir Ganga Ram hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
The study population includes patients equal to or more than 18 years of age admitted to the adult intensive careunit with severe ARDS (according to Berlin criteria) who are candidates for prone ventilationtherapy and have no contraindications for the placement of an oesophageal balloon catheter
Contraindications to esophageal balloon placement
Esophageal or nasopharyngeal pathology (such as tumors, sinusitis , epistaxis,ulcerations, recent surgery or bleeding varices) , Diverticulitis , Bronchopulmonary fistula ,Solid-organ transplantation , History of difficult intubation or airway management ,Duration of ARDS >=36 h or duration of mechanical ventilation >=96
Contraindications to prone positioning
Shock (eg, persistent mean arterial pressure <65 mmHg),Acute bleeding (eg, hemorrhagic shock, massive hemoptysis), Multiple fractures or trauma (eg, unstable fractures of femur, pelvis, face),Spinal instability, Pregnancy, Raised intracranial pressure >30 mmHg or cerebral perfusion pressure <60 mmHg, Tracheal surgery or sternotomy within two weeks
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the transpulmonary pressures by esophageal pressure measurement in supine andprone position in patients with severe acute respiratory distress syndromeTimepoint: Three consecutive readings of esophageal pressure, airway pressure and transpulmonary pressurewill be obtained from the ventilator display during 5 second pause of end expiration one hour aftercatheter placement in supine position and two hours after maintaining the prone position. Averageof these three readings will be calculated in both the positions and recorded.
- Secondary Outcome Measures
Name Time Method Compliance and PEEP requirements in supine and prone positionTimepoint: Supine and 2 hours after prone position