Skip to main content
MedPathMedPath Home
Clinical Trials/NL-OMON46412
NL-OMON46412
Recruiting
Not Applicable

Effect of positive transpulmonary pressures on intracranial pressure and cerebrovascular autoregulation in severe acute brain injury - Effect intrathoracic pressures on intracranial pressures

Radboud Universitair Medisch Centrum0 sites20 target enrollmentTBD
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
Radboud Universitair Medisch Centrum
Enrollment
20
Status
Recruiting
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Interventional

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Age \* 18 years
  • •Severe TBI defined as Glasgow Coma Score 3\-8
  • •Multimodal neuromonitoring, including at least intracranial pressure monitoring
  • •Acute respiratory distress syndrome (ARDS, according to the Berlin definition)

Exclusion Criteria

  • •\- Hemodynamic instability, despite fluid resuscitation and/or vasopressor use.
  • •\- Pneumothorax in last 3 days before the start of the study
  • •\- Signs and/or symptoms of brain herniation based on clinical symptoms and or CT cerebrum
  • •\- Pregnancy
  • •\- Status after decompressive craniectomy
  • •\- During or after Penthotal coma
  • •\- Unfavourable ventilator settings before start of the study (defined as plateau pressures \> 30 cm H2O, or FiO2 \> 60%)
  • •\- Intracranial pressure \> 20 mmHg for at least 5 minutes, despite the use of ICP lowering treatment
  • •\- Moribund (fixed pupils or signs of brainstem coning)
  • •\- History of oesophageal surgery

Outcomes

Primary Outcomes

Not specified

Similar Trials

Recruiting
Phase 4
Effect of Continuous Positive Airway Pressure on Time to Resolution of Dengue-associated Pleural EffusioDengue is a global problem and is common in more than 120 countries&#44mainly in Asia and South America. Each year millions of people are infected and up to 20&#44000 die.Dengue hemorrhagic fever&#44pleural effusion&#44Continuous Positive Airway Pressure
TCTR20200916008Mahidol Oxford Research Unit74
Completed
Not Applicable
Effect of continuous positive airway pressure in the treatment of refractory hypertension in patients with sever obstructive sleep apneaCondition 1: High blood pressure. Condition 2: Sleep apnoea.Essential (primary) hypertensionSleep apnoea
IRCT201108167346N1Arak University of Medical Sciences80
Recruiting
Not Applicable
Transpulmonary pressure measurement in the intansive care unit; single center observational studyPatients over 20 years old, respiratory management by mechanical ventilator in the intensive care unit
JPRN-UMIN000034147niversity of the Ryukyus20
Not yet recruiting
Phase 2
Personalising the ventilator settings to the patient by a simple measure of pressure in their foodpipe(esophagus) during a surgeryHealth Condition 1: K00-K95- Diseases of the digestive systemHealth Condition 2: N00-N99- Diseases of the genitourinary system
CTRI/2019/08/020556A
Completed
Not Applicable
Effects of continuous positive airway pressure on cardiac autonomic control, airway inflammation and oxidative stress in Thai patients with obstructive sleep apneaObstructive sleep apneaAirway inflammation
TCTR20160413001Faculty of Medicine, Khon Kaen University15