Double-blind randomized comparison of carbetocin versus oxytocin for decrease blood loss from cesarean section in low-risk uterine atony
Phase 2
- Conditions
- pregnant women with low-risk uterine atony cesarean section
- Registration Number
- TCTR20170702001
- Lead Sponsor
- faculty of medicine Vajira hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- Female
- Target Recruitment
- 122
Inclusion Criteria
1. At least 18 years old
2. singleton term uncomplicated pregnancy (37-42 weeks)
3. indication for cesarean section
4. regional anesthesia (carbetocin is licensed for use with regional anesthesia only)
Exclusion Criteria
1.contraindications to use uterotonic drugs (heart disease, high blood pressure, allergic medicine)
2.severe anemia (Hb ≤ 8 gm / dl)
3.Disease or used drug that results abnormal blood bleeding
4.fetal distress
5.High risk for PPH due to uterine atony
•prolong latent phase of labor
•history of PPH
•multiparity (childbirths >4 )
•massive blood loss before labor
•placenta previa
•placental abruption
• placenta adherence
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method amount of blood loss from cesarean section in low-risk uterine atony 24 hour after cesarean section blood that was sucked in operation and weighing sanitary napkin that used after cesarean section
- Secondary Outcome Measures
Name Time Method Blood transfusion 24 hour after cesarean section number of case that used blood transfusion,Hb, Hct level pre and post operative 24 hour after cesarean section CBC pre-operative and CBC at 24 hour after cesarean section,Urine output 24 hour after cesarean section urine volume in urine bag /on foley catheter,Admission days admission to discharge from hospital number of days ,additional uterotonic use 24 hour after cesarean section number of case that add uterotonic drugs,side effect drugs admission to discharge from hospital number of case that had symptom after intervention,cost of hospitalization admission to discharge from hospital cost of hospitalization in Thai Bath