caffeine speeds recovery from anesthesia

Phase 2

Recruiting

• Conditions: Anaesthesia

• Registration Number: PACTR202101897491424

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-06-11
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

normotensive patients
aged 18-60 years
(ASA physical status I or II,
BMI 18-35 Kg/m2)
scheduled for elective day case surgeries under general anaesthesia

Exclusion Criteria

•Pregnant patients,
•Breastfeeding
•Severe visual or auditory impairment
•Mental disorders or cognitive dysfunction.
•Cardiac, liver, neuromuscular, endocrine or kidney diseases,
•abnormal electrocardiogram findings
•Peptic ulcer disease, gastroesophageal reflux disease or malabsorption diseases.
•Severe anxiety.
•History of epilepsy, antipsychotic, antidepressant medications or any other neurological problem.
•Sensitivity to caffeine.
•Use of caffeine and other caffeine containing tablets or beverages or methyl xanthines within 2 days prior to the study.
•Cigarette smokers and alcohol and/or drug abusers.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the elapsed time after T0 until opening the eyes either spontaneously or upon verbal request repeated every 60 seconds by a blinded investigator.

Secondary Outcome Measures

Name	Time	Method
•The ET isoflurane, BIS level and minute volume will be observed continuously starting with isoflurane switching off till extubation. The last values before extubation will be recorded. ;•Mean arterial pressure, and heart rate ;•extubation time ;•The elapsed time from T0 to the time the patient stated his/her full name (commands will be given every 20 s by a blinded investigator).;Adverse events: the occurrence of pain, nausea and/or vomiting, shivering, seizures, agitation, and any other adverse event. The visual analog scale (VAS), grading 0 to 10 cm, will be used to evaluate pain (0 = no pain to 10= the most pain I have ever felt) and nausea (0 = no nausea to 10 = as nauseous as I have ever been) during recovery. Pain requiring rescue medications (VAS>4) will be recorded. Agitation will be screened by modified Richmond sedation score