NCT06787066招募中1 期
Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Sympathetic transduction
研究概览
简要总结
The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Assigned female at birth
- •18-70 years of age
- •Body mass index (BMI) <30 kg/m2
排除标准
- •Assigned male at birth
- •Pregnancy, breastfeeding
- •Body mass index ≥30 kg/m2
- •Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
- •Current smoking/nicotine use
- •Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
- •Nerve/neurologic disease
- •Cardiovascular, hepatic, renal, respiratory disease
- •Blood pressure ≥140/90 mmHg
- •Diabetes, Polycystic ovarian syndrome
- •Communication barriers
- •Prescription medications
研究组 & 干预措施
Women
Other
Women ages 18-70 years will participate.
干预措施: Propranolol Hydrochloride (Drug)
Women
Other
Women ages 18-70 years will participate.
干预措施: Phentolamine Injection (Drug)
结局指标
主要结局
Sympathetic transduction
时间窗: 1 day (single study visit)
Assessing the relative change in blood flow (Doppler ultrasound) following an increase in sympathetic nerve activity.
次要结局
- Blood flow(1 day (single study visit))
- Muscle sympathetic nerve activity(1 day (single study visit))
研究者
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia
研究点 (1)
Loading locations...
相似试验
进行中（未招募）
1 期
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in ObesityHealthyInsulin ResistanceObesityNCT03318094Vanderbilt University Medical Center36
招募中
1 期
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)HypertensionObesityNCT04838678University of Texas Southwestern Medical Center100
已完成
不适用
Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic DenervationArterial HypertensionResistant Arterial HypertensionNCT03243045National Institute of Cardiology, Laranjeiras, Brazil20
已完成
1 期
Sympathetic and Vascular Function in Takotsubo SyndromeTakotsubo CardiomyopathyNCT05768542Danderyd Hospital31
进行中（未招募）
不适用
Sympathetic activation, microcirculation, haemostasis and inflammation in diabetic and non-diabetic kidney disease: disease modification by vitamin D receptor activation - VDRA and CKDEUCTR2007-006274-29-SEKarolinska Institutet at Danderyd University Hospital