Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

Early Phase 1

Not yet recruiting

• Conditions: Menopause
• Interventions: Drug: Propranolol Hydrochloride; Drug: Phentolamine Injection

• Registration Number: NCT06787066
• Lead Sponsor: University of Missouri-Columbia

Brief Summary

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-01
• Study First Submitted: 2025-01-10
• Study First Submitted QC: 2025-01-15
• Last Update Submitted: 2025-03-24
• Study First Posted: 2025-03-25
• Last Update Posted: 2025-03-28
• Study Start: 2025-05
• Primary Completion: 2026-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 75

Inclusion Criteria

• Assigned female at birth
• 18-70 years of age
• Body mass index (BMI) <30 kg/m2

Exclusion Criteria

• Assigned male at birth
• Pregnancy, breastfeeding
• Body mass index ≥30 kg/m2
• Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
• Current smoking/nicotine use
• Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
• Nerve/neurologic disease
• Cardiovascular, hepatic, renal, respiratory disease
• Blood pressure ≥140/90 mmHg
• Diabetes, Polycystic ovarian syndrome
• Communication barriers
• Prescription medications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Women	Propranolol Hydrochloride	Women ages 18-70 years will participate.
Women	Phentolamine Injection	Women ages 18-70 years will participate.

Primary Outcome Measures

Name	Time	Method
Sympathetic transduction	1 day (single study visit)	Assessing the relative change in blood flow (Doppler ultrasound) following an increase in sympathetic nerve activity.

Secondary Outcome Measures

Name	Time	Method
Blood flow	1 day (single study visit)	Measuring femoral artery blood flow using Doppler ultrasound.
Muscle sympathetic nerve activity	1 day (single study visit)	Measuring the sympathetic nerve activity of the fibular nerve using a microelectrode .