NCT06787066
Recruiting
Early Phase 1
Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
University of Missouri-Columbia1 site in 1 country75 target enrollmentStarted: July 10, 2025Last updated:
Overview
- Phase
- Early Phase 1
- Status
- Recruiting
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Sympathetic transduction
Overview
Brief Summary
The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Assigned female at birth
- •18-70 years of age
- •Body mass index (BMI) \<30 kg/m2
Exclusion Criteria
- •Assigned male at birth
- •Pregnancy, breastfeeding
- •Body mass index ≥30 kg/m2
- •Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
- •Current smoking/nicotine use
- •Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
- •Nerve/neurologic disease
- •Cardiovascular, hepatic, renal, respiratory disease
- •Blood pressure ≥140/90 mmHg
- •Diabetes, Polycystic ovarian syndrome
Arms & Interventions
Women
Other
Women ages 18-70 years will participate.
Intervention: Propranolol Hydrochloride (Drug)
Women
Other
Women ages 18-70 years will participate.
Intervention: Phentolamine Injection (Drug)
Outcomes
Primary Outcomes
Sympathetic transduction
Time Frame: 1 day (single study visit)
Assessing the relative change in blood flow (Doppler ultrasound) following an increase in sympathetic nerve activity.
Secondary Outcomes
- Blood flow(1 day (single study visit))
- Muscle sympathetic nerve activity(1 day (single study visit))
Investigators
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia
Study Sites (1)
Loading locations...
Similar Trials
Active, not recruiting
Phase 1
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in ObesityInsulin ResistanceHealthyObesityNCT03318094Vanderbilt University Medical Center36
Recruiting
Early Phase 1
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)HypertensionObesityNCT04838678University of Texas Southwestern Medical Center100
Completed
Not Applicable
Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic DenervationArterial HypertensionResistant Arterial HypertensionNCT03243045National Institute of Cardiology, Laranjeiras, Brazil20
Completed
Phase 1
Sympathetic and Vascular Function in Takotsubo SyndromeTakotsubo CardiomyopathyNCT05768542Danderyd Hospital31
Active, not recruiting
Not Applicable
Sympathetic activation, microcirculation, haemostasis and inflammation in diabetic and non-diabetic kidney disease: disease modification by vitamin D receptor activation - VDRA and CKDEUCTR2007-006274-29-SEKarolinska Institutet at Danderyd University Hospital