difference of intravenous versus nebulised dexmedetomidine for attenuation of sympathetic response to laryngoscopy & endotracheal intubatio
- Conditions
- Health Condition 1: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems
- Registration Number
- CTRI/2023/06/054006
- Lead Sponsor
- Somya Pareek
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.ASA grades 1 & 2 (American Society of Anesthesiologists physical status)
2.Age group 18- 65 years
3.Either gender
4.Patients scheduled for elective surgery under general anaesthesia with endotracheal intubation
Patients fulfilling the above criteria consenting to participate in the study.
1.Patient refusal.
2.Patients less than 18 years and more than 65 years of age.
3.Patients scheduled for general anaesthesia without endotracheal intubation such as mask ventilation, use of laryngeal mask airways, sedation, monitored anaesthetic care, or surgery duration more than 90mins.
4.Patients coming for surgery under regional anaesthesia.
5.Patients belonging to ASA grade >= III.
6.Patients undergoing emergency surgeries.
Obese individuals (body mass index > 30 kg/m2)
7.Patients with known or unanticipated difficult intubation and those requiring more than 15secs or two attempts at laryngoscopy.
8.Patients with arrythmias.
9.Patients with known allergy to dexmedetomidine, and those on anti-hypertensive medications or preoperative drugs that could be potential confounders (clonidine, gabapentin, pregabalin, steroids)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SBP,DBP, SpO2, MAP, HRTimepoint: baseline, After giving, immediately after intubation, after 1 min, following 3 min, 5 min, 7 min, 10 min,15 min,30 min, 45 min, 60 min, 90 min
- Secondary Outcome Measures
Name Time Method Post operative sore throat, analgesic dose requirements, sedationTimepoint: baseline, After giving, immediately after intubation, after 1 min, following 3 min, 5 min, 7 min, 10 min,15 min,30 min, 45 min, 60 min, 90 min