Inhalational versus intravenously administered dexmedetomidine for blunting hemodynamic responses to laryngoscopy and intubation: a randomized double blind comparative study
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/10/058557
- Lead Sponsor
- MAHATMA GANDHI MEDICAL COLLEGE AND HOSPITA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Elective surgeries under general anaesthesia
Patients of either sex having age 18-55years
Body weight 50 to 70 kgs
American society of anaesthesiologists (ASA) physical status I – II
Patient’s written and informed consent
Patient refusal for the anaesthetic technique.
Patients having mouth opening < 3 Cms or predicted difficult airway.
Patient with severe renal, hepatic, respiratory and cardiac disease.
Any bleeding disorder or patient on anticoagulants
History of allergy to study drug
Patient belonging to ASA CLASS III, IV & V
Patients on any sedatives, antipsychotics, antidepressants, anxiolytics or anticonvulsants and betablockers.
Patient with any nasal pathology like nasal ulcer, nasal polyp, nasal septum deviation.
Patients with difficult airway like cervical spine instability, facial fractures, partially obstructing laryngeal lesions (e.g., papilloma), craniofacial abnormalities, and temporo mandibular joint ankylosis.
Patient coming for emergency surgery
Pregnant patients
H/O Covid infection during last 3 months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of the study will be to compare intravenous dexmedetomidine with nebulised dexmedetomidine as premedication for attenuation of laryngoscopic and intubation response.Timepoint: Vitals will be recorded on starting the study drugs and after every 5 minutes interval till the endotracheal tube is inserted. Also, vitals will be recorded immediately after intubation, 1,3 and 5 minutes after intubation thereafter every 5 minutes up to 30 minutes after insertion of endotracheal tube than at extubation.
- Secondary Outcome Measures
Name Time Method The secondary outcome of the study will be to study and compare the sedation score and <br/ ><br>to study and compare the complications encountered with the two routesTimepoint: Sedation score will be calculated at 20 mins after giving drug and any complications will be noted during whole procedure.