To know how dexmedetomidine (used as sedative, antihypertensive) used via 2 different routes i.e., inhalation or through intravenous infusion helps in reducing blood pressure and heart rate while inserting a tube in trachea (windpipe) for providing general anaesthesia
Not Applicable
Completed
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/05/052183
- Lead Sponsor
- Reshma B M
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. Patients undergoing elective surgeries under general anaesthesia
2. Patients belonging to American Society of Anaesthesiologists Physical Status (ASA-PS) 1 and 2
Exclusion Criteria
1. Patient refusal
2. Patient allergic to study drug
3. BMI > 30 kg/m2.
4. Patients with difficulty airway, unanticipated difficult laryngoscopy and intubation
( lasting > 15 seconds or more than 2 attempts at intubation)
5. Pregnancy and lactation.
6. Patient on opioids, sedatives, or beta blockers.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To assess the effect of nebulized and intravenous dexmedetomidine on mean <br/ ><br>arterial pressure response following laryngoscopy.Timepoint: 1. Following laryngoscopy at baseline, every minute for 5 minutes and at 10th minute.
- Secondary Outcome Measures
Name Time Method 1. To determine the dose sparing effect of induction dose of propofol. <br/ ><br>2. To assess the sedation scores preoperatively, using Modified Ramsay sedation score. <br/ ><br>3.To assess for side effects if any.Timepoint: 1. After induction of anaesthesia. <br/ ><br>2. Every 5 minutes after drug administration for 30 minutes. <br/ ><br>3. From start of drug administration till end of surgery. (every 5 minutes)