Microvesicle Production After Acute Trauma and Its Clinical Impact on Venothromboembolism
Completed
- Conditions
- Venothromboembolism
- Registration Number
- NCT01264458
- Lead Sponsor
- Mayo Clinic
- Brief Summary
The purpose of this research study is to look at how trauma affects the ability of blood to clot. The blood of people who suffer a traumatic injury can under-clot or over-clot, and this research study will look at blood drawn from people after they suffer a traumatic injury to see how well their blood clots.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1234
Inclusion Criteria
- Male and female patients 18 years of age or older
- Blunt trauma patients including those with closed head injury
- Penetrating trauma patients
Read More
Exclusion Criteria
- Are on therapeutic anticoagulation
- Have preexisting coagulopathy
- Patients greater than 12 hours from time of injury
- Have history of malignancy or preexisting diagnosis of sepsis or renal failure
- Patients with burn injuries
- Male and female patients younger than 18 years of age
- Pregnant patients
Read More
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Estimate the distribution over time of procoagulant Microvesicles (MVs) concentration by cell of origin and endogenous thrombin potential (ETP). 6 months Determine the cumulative incidence of Venothromboembolism (VTE) within three months after major trauma and test the distribution of procoagulant MV concentration and endogenous thrombin generation potential over time as potential predictors of VTE. 4 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States