Microvesicle Production After Acute Trauma and Its Clinical Impact on Venothromboembolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 1,234
- 试验地点
- 1
- 主要终点
- Estimate the distribution over time of procoagulant Microvesicles (MVs) concentration by cell of origin and endogenous thrombin potential (ETP).
研究概览
简要总结
The purpose of this research study is to look at how trauma affects the ability of blood to clot. The blood of people who suffer a traumatic injury can under-clot or over-clot, and this research study will look at blood drawn from people after they suffer a traumatic injury to see how well their blood clots.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female patients 18 years of age or older
- •Blunt trauma patients including those with closed head injury
- •Penetrating trauma patients
排除标准
- •Are on therapeutic anticoagulation
- •Have preexisting coagulopathy
- •Patients greater than 12 hours from time of injury
- •Have history of malignancy or preexisting diagnosis of sepsis or renal failure
- •Patients with burn injuries
- •Male and female patients younger than 18 years of age
- •Pregnant patients
结局指标
主要结局
Estimate the distribution over time of procoagulant Microvesicles (MVs) concentration by cell of origin and endogenous thrombin potential (ETP).
时间窗: 6 months
Determine the cumulative incidence of Venothromboembolism (VTE) within three months after major trauma and test the distribution of procoagulant MV concentration and endogenous thrombin generation potential over time as potential predictors of VTE.
时间窗: 4 years
次要结局
未报告次要终点
研究者
Myung S. Park
Assistant Professor of Surgery
Mayo Clinic