Relationship Between Serum 1,25-dihydroxy Vitamin D and Markers of Bone Metabolism in Renal Dysfunction Patients

Completed

• Conditions: Chronic Kidney Disease-Mineral and Bone Disorder

• Registration Number: NCT05399251
• Lead Sponsor: Aga Khan University Hospital, Pakistan

Brief Summary

This cross-sectional study was conducted, including those subjects tested for 1,25(OH)2D during Jan 2015-Dec 2021. Estimated glomerular filtration rate (eGFR) was calculated and subjects were classified into chronic kidney disease (CKD) stages. Associations between biochemical marker, calcium, phosphorus, magnesium, alkaline phosphatase, 1,25(OH)2D and CKD stages was determined.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-01
• Primary Completion: 2021-12-30
• Study Completion: 2021-12-30
• Study First Submitted: 2022-02-14
• Status Verified: 2022-05
• Study First Submitted QC: 2022-05-29
• Last Update Submitted: 2022-05-29
• Study First Posted: 2022-06-01
• Last Update Posted: 2022-06-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1553

Inclusion Criteria

• Data of serum 1,25(OH)2D available

Exclusion Criteria

• Serum1,25(OH)2D is not available

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
concentration of serum calcium in mg/dl in five stages of chronic kidney disease	7 years	in renal tubules, 1,25- dihydroxy vitamin D increase reabsorption of calcium from renal filtrate and thus stabilize blood calcium levels. in CKD, with deterioration of kidney function, stage V, the levels of calcium drops resulting in hypocalcemia.
concentration of serum 1,25 dihydroxy vitamin D in U/L in five stages of chronic kidney disease	7 year	In CKD, 1-alfa-hydroxylase activity in the kidneys is reduced, leading to decreases in the level of the activated form of vitamin D (1,25- dihydroxy vitamin D), resulting in secondary hyperparathyroidism and bone disease. This study aimed to determine the concentration of 1,25 dihydroxy vitamin D in different stages of CKD.