The effects of exercise on cognitive function and the formation of new neurons in the hippocampus in the brain.
Recruiting
- Conditions
- Healthy volunteers are used to elucidate the biological processes underlying the effects of exercise on the brain. This could in the future be of possible benefit for patients with neurodegenerative disorders, depression, dementia.NL: Neurodegeneratieve stoornissen, dementie, depressie
- Registration Number
- NL-OMON29541
- Lead Sponsor
- Academic Medical Center, Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 52
Inclusion Criteria
Age 18-30 years, BMI < 30 kg/m2, stable exercise history 3 months prior to study inclusion.
Exclusion Criteria
current intensive sports (>3 times/week), excessive smoking (>1 pack/day), alcohol (>21 units/week), or other regular drug use, history of chronic renal insufficiency, prior allergic reaction to Gadolinium-containing compounds, psychiatric disorders and general contraindications for MRI.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - 1.28 ppm peak concentration in hippocampus, to assess neurogenesis (1H-MRS)<br /><br>- new vascularization (rCBV in hippocampus using contrast-enhanced MRI)<br /><br>- pattern separation
- Secondary Outcome Measures
Name Time Method - hippocampal volume (T1-weighted MRI);<br /><br>- VO2max (cardiopulmonary exercise test);<br /><br>- neuropsychological functioning (cognitive and neuropsychological tests);<br /><br>- lifestyle and dietary patterns (questionnaires);<br /><br>- endothelial and neuronal growth factors (blood sampling)<br>