Systemic Propranolol for the Treatment of Paediatric Patients With Infantile Hemangiomas

Completed

• Conditions: Infantile Haemangiomas
• Interventions: Drug: propranolol

• Registration Number: NCT04651049
• Lead Sponsor: Qilu Hospital of Shandong University

Brief Summary

This is retrospective study. The patients treated with oral propranolol at a dose of 2.0 mg/kg per day. Growth parameters (height and weight) were measured at the beginning, the end of treatment and 2 years after treatment. The weight-for-age Z-score (WAZ), height-for-age Z-score (HAZ) and weight-for-height Z-score (WHZ) calculated by the WHO Anthro software were used to assess physical development, and the WHO Child Growth Standards were used as the standards.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-07-15
• Primary Completion: 2017-12-15
• Study Completion: 2020-02-10
• Status Verified: 2020-08
• Study First Submitted: 2020-11-18
• Study First Submitted QC: 2020-11-25
• Last Update Submitted: 2020-11-25
• Study First Posted: 2020-12-03
• Last Update Posted: 2020-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

• IHs diagnosed by medical history and physical examination
• no previous treatment with other medications

Exclusion Criteria

• a history or risk of asthma, reactive airway disease, impaired renal or liver function, heart defects or arrhythmia, hypotension and hypersensitivity to propranolol
• Infants who did not adhere to the treatments or attend follow-up visits
• Infants with other known risk factors for developmental delay or growth restriction, such as prematurity, small for gestational age, or other major congenital malformations, were also excluded
• No other treatment was used during the oral propranolol course

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Propranolol treatment group	propranolol	-

Primary Outcome Measures

Name	Time	Method
Change on the height of the patients	at the beginning of the treatment, at the end of treatment and 2 years after the treatment	we recorded the height of the patients in meters.
Change on the weight of the patients	at the beginning of the treatment, at the end of treatment and 2 years after the treatment	we recorded the weight of the patients in kilograms.