Hemodynamic Effects of Ketamine versus Etomidate during Induction of Anesthesia in Sepsis and Septic Shock Patients Undergoing Surgery: A Prospective Randomized Controlled Trial
Phase 3
- Conditions
- Sepsis and Septic Shock Patients Undergoing SurgeryKetamine, Etomidate, Sepsis, Septic shock, Hemodynamic
- Registration Number
- TCTR20210820002
- Lead Sponsor
- Khon kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 68
Inclusion Criteria
1. 18-65 years of age
2. Undergoing general anesthesia with endotracheal intubation
Exclusion Criteria
1. already intubation
2. have a contraindication for arterial canulation
3.contraindication for ketamine used such as increase ICP, increase IOP, myocardial infraction
4. contraindication for etomidate such as adrenal insufficiency
5.suspected difficult airway
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean arterial pressure (MAP) first 10 minutes after induction of anesthesia MAP measure by invasive blood pressure monitoring
- Secondary Outcome Measures
Name Time Method Incidence of post-induction hypotension first 10 minutes after induction of anesthesia MAP, Dose of norepinephrine,Heart rate first 10 minutes after induction of anesthesia Heart rate by ECG monitor,Amount of fluid resuscitation 30 minutes after induction of anesthesia ml of fluid,Urine output 30 minutes after induction of anesthesia ml of urine,Dose of vasopressor 10 minutes after induction of anesthesia Noreponephrine as mcg/kg/min,ABG value before induction and 30 minutes after induction of anesthesia Arterial blood sampling