Examining the role of gut taste receptors in food preferences, weight loss, and metabolic improvements after bariatric surgery.

Not Applicable

Recruiting

• Conditions: obesity; bariatric surgery; Metabolic and Endocrine - Metabolic disorders; Surgery - Other surgery

• Registration Number: ACTRN12623000233628
• Lead Sponsor: St Vincent's Hospital Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-03-06
• Last Update Posted: 13 March 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Adults (age 18 years or over)
2. Waiting to undergo sleeve gastrectomy or Roux-en-Y gastric bypass

Exclusion Criteria

1. Using medication for the treatment of diabetes and/or obesity
2. Waiting to undergo revisional surgery
3. Previous intestinal surgery that has resulted in alteration to stomach or small bowel anatomy
4. Unable to provide informed consent

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in gastrointestinal expression of taste-related genes before vs 12 months after bariatric surgery<br><br>This will be assessed through quantitative PCR and protein analysis of taste receptor and taste-related genes in the stomach and small bowel mucosal biopsies. [Pre-operatively<br>Day of surgery (after pre-operative very low energy diet [VLED])<br>12-months post-surgery<br>];Preference for highly palatable sweet foods before vs 12 months after bariatric surgery <br><br>This will be assessed by the Sweet Taste Questionnaire.[Pre-operatively<br>Day of surgery (after pre-operative very low energy diet [VLED])<br>12-months post-surgery];Preference for highly palatable fatty foods before vs 12 months after bariatric surgery <br><br>This will be assessed by the Fat Preference Questionnaire. [Pre-operatively<br>Day of surgery (after pre-operative very low energy diet [VLED])<br>12-months post-surgery]

Secondary Outcome Measures

Name	Time	Method
Alcohol consumption and drinking preferences.<br><br>Assessed via The Drinking Behaviour Questionnaire[Pre-operatively<br>Day of surgery (after pre-operative very low energy diet [VLED])<br>12-months post-surgery<br>];Body weight <br><br>Measured on calibrated medical weighing scales in kilograms and change from pre-operative to day-of-surgery to post-operative follow-up calculated as percentage of total weight loss.[Pre-operatively<br>Day of surgery (after pre-operative very low energy diet [VLED])<br>12-months post-surgery<br>];Fasting blood glucose[Pre-operatively<br>Day of surgery (after pre-operative very low energy diet [VLED])<br>12-months post-surgery];Fasting lipid profile <br><br>Assessed via serum analysis.[Pre-operatively<br>Day of surgery (after pre-operative very low energy diet [VLED])<br>12-months post-surgery]