Effects of normocaloric vs. hypocaloric enteral nutrition on whole-body protein turnover in critically ill patients

Not Applicable

Recruiting

• Conditions: Critical illness; Diet and Nutrition - Other diet and nutrition disorders; Metabolic and Endocrine - Other metabolic disorders

• Registration Number: ACTRN12614000476639
• Lead Sponsor: Prof Olav Rooyackers

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-05-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Critically ill patients on stable, normocaloric, enteral nutrition nutrition via nasogastric feeding tube/gastrostomy/jejunostomy

Exclusion Criteria

Blood transfusion during study period, intolerance of enteral nutrition at time of recruitment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Whole body net protein balance<br><br>Whole-body protein breakdown and synthesis is calculated from arterial plasma enrichments of isotope labeled phenylalanine and tyrosine tracers. The arithmetic difference of breakdown and synthesis is the net protein balance which is the main outcome. Intermediary calculations are also reported for clarity.[Parameters of whole body protein turnover are measured 22 hrs post initiation of normocaloric enteral nutrition and 22 hrs post initiation of hypocaloric enteral nutrition ]

Secondary Outcome Measures

Name	Time	Method
Splanchnic extraction fraction of dietary phenylalanine is calculated from arterial plasma enrichments of isotope labeled phenylalanine and tyrosine tracers. [Splanchnic extraction fraction of dietary phenylalanine is measured 22 hrs post initiation of normocaloric enteral nutrition and 22 hrs post initiation of hypocaloric enteral nutrition ];Plasma amino acid profile[Plasma amino acid profile is measured before intervention, 22 hrs post initiation of normocaloric enteral nutrition, and 22 hrs post initiation of hypocaloric enteral nutrition ]