Pediatric Eye Care Investigated Team
- Conditions
- Systemic DiseaseEye DiseasesOcular Surface DiseaseChildren
- Registration Number
- NCT05247099
- Brief Summary
Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases.
- Detailed Description
Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases.
All participants will be recruited from Zhongshan Ophthalmic Center, Sun Yat-sen University and Affiliated Foshan Maternity \& Child Healthcare Hospital, Southern Medical University. Only children with written informed consent from their parents can participate in this study.
Participants will be excluded for (1) age\>18; (2) previous use of orthokeratology lenses or low-concentration atropine; (3) allergy to compound tropicamide eye drop; (4) any history of ocular surgery.
All participants will undergo optometry and biometric measurements by a trained team. The axial length (AL), central corneal thickness (CCT), anterior corneal radii of curvature, anterior chamber depth (ACD), lens thickness (LT), the curvature power of the central flat meridian (K1) and the central steep meridian (K2), the ocular surface and fundus will be measured. All measurements will be taken in room light condition (1000 lux).
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 1000
-
- Age≤18
-
- Cooperate with eye examination
-
- Sign informed consent
-
- Cannot cooperate with eye examination
-
- The researcher believes that the patient is not suitable to participate in the study.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change of the lipid layer of tear film baseline, 24th months change of the lipid layer of tear film in nanometers
change of the non-invasive tear break-up time baseline, 24th months change of the non-invasive tear break-up time in seconds
- Secondary Outcome Measures
Name Time Method intraocular pressure baseline, 6th months, 12th months, 18th months, 24th months the intraocular pressure in mm Hg
Anterior chamber depth baseline, 6th months, 12th months, 18th months, 24th months Anterior chamber depth in millimeters
Eye axis length baseline, 6th months, 12th months, 18th months, 24th months Eye axis length in millimeters
non-invasive tear break-up time 6th months, 12th months, 18th months non-invasive tear break-up time in seconds
vision baseline, 6th months, 12th months, 18th months, 24th months spherical equivalent in diopters
central corneal thickness baseline, 6th months, 12th months, 18th months, 24th months central corneal thickness in millimeters
Retina thickness baseline, 6th months, 12th months, 18th months, 24th months retina thickness in millimeters
Corneal curvature baseline, 6th months, 12th months, 18th months, 24th months Corneal curvature in diopters
Lens thickness baseline, 6th months, 12th months, 18th months, 24th months Anterior chamber depth in millimeters
choroid thickness baseline, 6th months, 12th months, 18th months, 24th months choroid thickness in millimeters
the lipid layer of the tear film 6th months, 12th months, 18th months the lipid layer of the tear film in nanometers