NCT06758895尚未招募不适用
Cardiac Magnetic Resonance Predictors of Outcome of Rhythm Control in Patients with Atrial Fibrillation/Flutter
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Recurence in patient with AF or flutter after pharmacological or interventional rythm control
研究概览
简要总结
evaluate the impact of various features in CMR on the mid-term/long-term success rate of rhythm control for paroxysmal atrial fibrillation/flutter .
详细描述
- Atrial fibrillation/flutter are widely prevalent.
- Reported antiarrhythmic drug efficacy to restore & maintain sinus rhythm is 52% which is far from optimal.
- On the other hand, 5-year arrhythmia-free survival after catheter ablation was previously reported to be 63%.
- Therefore, there is a need for better characterization of the underlying atrial substrate, to improve treatment outcomes in terms of efficacy and safety
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age>18 years.
- •Patients undergoing successful cardioversion (pharmacologic or electric) for atrial fibrillation/flutter, OR symptomatic patients with paroxysmal atrial fibrillation/flutter scheduled for trans-catheter ablation.
- •Index cardioversion OR Index ablation procedure.
排除标准
- •LA thrombus on TEE or CMR.
- •Contraindications to CMR.
- •Contraindications to Gd-based contrast.
结局指标
主要结局
Recurence in patient with AF or flutter after pharmacological or interventional rythm control
时间窗: Baseline
* Non-invasive rhythm control arm: Predictors of atrial fibrillation recurrence within 6 months of cardioversion or the need for ≥2 cardioversions in the 1st year after initial cardioversion. * Ablation arm: Predictors of success rate (acute and mid term) of ablation on multivariable logistic regression analysis.
次要结局
- parameters for safe ablation(Baseline)
研究者
Maryam Ashraf Abd El-Naeem Sayed
Resident Doctor at Assiut University Heart Hospital
Assiut University
研究点 (1)
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