Evaluation of the effect of sildenafil and melatonin on fertility outcomes in women with poor ovarian response
Phase 3
Recruiting
- Conditions
- Female infertility due to poor ovarian response.Female infertility of other originN97.8
- Registration Number
- IRCT20160524028038N15
- Lead Sponsor
- Bandare-abbas University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 88
Inclusion Criteria
Aged 18 to 45 years
Not using other vasodilator drugs such as nitric oxide and calcium channel blockers
Normal semen analysis
Poor ovarian response
Exclusion Criteria
Patients with other endocrine disorders such as hyperprolactinemia, PCOS, etc.
History of ovarian surgery or ovarian endometrioma
Smoker
Cardiovascular disorders
Unwillingness to cooperate
Sildenafil sensitivity and intolerance to side effects (hot flashes, vision disorders, severe drop in blood pressure and hearing disorders)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Oocyte Quality. Timepoint: 2-3 hrs. after oocyte collection. Method of measurement: Microscopic Evaluation.;Number of retried oocyte. Timepoint: On day of oocyte retrieval. Method of measurement: Counting number of total oocytes with microscope.;Number of embryo. Timepoint: On the 2nd day after ICSI. Method of measurement: Observation with microscope.
- Secondary Outcome Measures
Name Time Method