Bicarbonate in Patients With Out-of-hospital Cardiac Arrest

Phase 2

Completed

• Conditions: Cardiac Arrest; Metabolic Acidosis
• Interventions: Drug: Normal saline; Drug: Sodium bicarbonate

• Registration Number: NCT02303548
• Lead Sponsor: Asan Medical Center

Brief Summary

A pilot study to evaluate the effect of sodium bicarbonate administration on cardiopulmonary resuscitation results and outcomes in cardiac arrest patient with severe metabolic acidosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2014-11-23
• Study First Submitted QC: 2014-11-25
• Study First Posted: 2014-12-01
• Primary Completion: 2016-02
• Study Completion: 2016-02
• Results First Submitted: 2019-07-07
• Results First Submitted QC: 2019-07-07
• Results First Posted: 2019-07-31
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-28
• Last Update Posted: 2022-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• adult cardiac arrest patient with arterial pH <7.1 or bicarbonate <10mmEq/L checked at 10 minutes of cardiopulmonary resuscitation

Exclusion Criteria

• age <18 trauma patient Do Not Resuscitate state

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2 (Normal saline)	Normal saline	Normal saline 50cc intravenous injection over 2 min
1 (Sodium bicarbonate)	Sodium bicarbonate	Sodium bicarbonate 50cc (50mEq) intravenous injection over 2 min

Primary Outcome Measures

Name	Time	Method
Return of Spontaneous Circulation (ROSC)	checked during CPR, duration of ROSC >20 min	Percentage of Participants with Return of Spontaneous Circulation (ROSC)