Cerebral perfusion in patients with severe aortic valve stenosis undergoing aortic valve replacement.

Completed

Conditions: blood circulation
Cerebral perfusion
10046973

Registration Number: NL-OMON44893

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 95

Inclusion Criteria

Cohort A (N<=30):
* Age between 50-75 years
* Presence of aortic stenosis (aortic valve area less than 1 cm2)
* Eligible for a surgical aortic valve replacement (AVR)
* Expected aortic valve size of 23-25 mm;Cohort B (N<=30):
Age between 50-95 years
* Presence of aortic stenosis (aortic valve area less than 1 cm2)
* Eligible for transcatheter aorta valve implantation (TAVI)

Exclusion Criteria

Cohort A:
* Additional complex surgical procedures indicated (e.g. restoration of aortic root)
* Medical history of neurological disease, active malignant disease/ cardio- toxic treatment and/or venous insufficiency
* Contraindication to MRI exposure (*vragenlijst MRI onderzoek*)
* Smoking or having smoked less than 10 years ago;Cohort B:
* Medical history neurological disease, active malignant disease/ cardio- toxic treatment and/or venous insufficiency
* Contraindication to MRI exposure (*vragenlijst MRI onderzoek*)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cerebral perfusion in rest and in response to moderate exercise (handgripping<br /><br>or light cycling) and a visual stimulus in patients with aortic valve stenosis<br /><br>(prior to and after aortic valve replacement) and healthy age-matched<br /><br>controls. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Cerebral perfusion in rest and in response to exercise in patients and<br /><br>healthy controls at both arterial (TCD) and microvascular level (arterial spin<br /><br>labeling MRI).</p><br>