How can we improve the bloof flow in the brain during bypass surgery of the brain?
- Conditions
- Patients with an indication for an extracranial-intracanial bypass (e.g. Moya Moya Disease, occluded carotid artery, giant aneurysm)MedDRA version: 20.0Level: LLTClassification code 10029999Term: Occlusion carotidSystem Organ Class: 100000004852MedDRA version: 20.1Level: LLTClassification code 10002333Term: Aneurysm cerebralSystem Organ Class: 100000004852MedDRA version: 20.1Level: LLTClassification code 10002337Term: Aneurysm intracranialSystem Organ Class: 100000004852Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
- Registration Number
- EUCTR2018-002008-15-NL
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 10
Adults, aged 18 years or above
Indication for extracranial-intracranial bypass surgery
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 8
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 2
Patients within two weeks after a subarachnoid hemorrhage
Language barrier
Pregnancy
Hypertrophic cardiomyopathy
Left ventricular outflow tract obstruction
Severe, untreated, ventricular arrhytmia
Severe hyperthyroidism
Recent myocardial infarction (<30days) or unstable angina
Hypersensitivity for dobutamine or phenylephrine
Mean arterial blood pressure < 60 mmHg under general anesthesia before start of the study period
Systolic blood pressure > 180 mmHg under general anesthesia before start of the study period
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method