How can we improve the blood flow to the brain during the construction of a bypass in the brain?
Completed
- Conditions
- Indicatie for an extracranial-intracranial bypass: either flow augmentation for patients with steno-occlusive vascular disease such as moyamoya disease or flow preservation when a major artery has to be sacrificed to treat an underlying disease such as a tumor of the central skull base or a complex intracranial aneurysm.
- Registration Number
- NL-OMON23040
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
none
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Adults, aged 18 years or above at day of surgery
Indication for extracranial-intracranial bypass surgery
Exclusion Criteria
Patients within two weeks after a subarachnoid hemorrhage
Language barrier
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method First, we will measure the graft flow rate to be used as a reference for graft perfusion. Afterwards the cardiac output or blood pressure is increased. Our main study parameter will be the mean (sd) change in graft flow for an increase in cardiac output compared to the reference phase and the mean (sd) change in graft flow for an increase in blood pressure, compared to the reference phase.
- Secondary Outcome Measures
Name Time Method Secondary endpoints are the absolute difference in increase (or decrease) in graft flow rate, cardiac output and blood pressure between dobutamine and phenylephrine treatment, as compared to the reference stage.