To know the effect of using hydroxyethyl starch with lignocaine for reduction of pain that occurs during administartion of propofol

Not yet recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2023/06/053406

Lead Sponsor: Dayanand Medical College and Hopsital

Brief Summary: Propofol is the most widely used intravenous induction agent in anaesthesia. Pain on propofol injection is a common problem.Even with multimodal techniques,pain on propofol injection is not abolished completely. Hydroxyethyl Starch(HES),a colloid,is a clinically safe and well tolerated complex polysaccharide and has the capacity to modify endothelial cell junctions and permeablity of the vascular endothelium.Pre administration of HES may prevent contact activation of propofol which may in turn lead to reduced pain during propofol injection.A prospective,double blind,randomized study will be conducted on a total of 206 ASA I and II patients of age 18-65 yrs undergoing elective surgery under general anaesthesia who will be randomly allocated into group ’H’ and ’S’ of 103 each. Patients in group ’H’ will be administered 50 ml of 6% HES with 2% lignocaine(1mg/kg) while patients in group ’S’ will be administerd equal volume of 0.9% saline with 2% lignocaine 2mins before induction with 1% propofol(2mg/kg).The incidence and severity of pain on propofol injection will be calculated using Numerical Pain Rating Scale every 15 secs till loss of verbal command. Our aim of the study is to compare the incidence and severity of pain on propofol injetion pre administered with 6%HES with 2% lignocaine or 0.9% saline with 2% lignocaine during induction of anaesthesia.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 206

Inclusion Criteria

Adult patients of American Society of Anaesthesiologists(ASA) physical status I and II 18-65 yrs old either gender undergoing elective surgery under general anaesthesia.

Exclusion Criteria

Emergency surgeries or hemodynamically unstable patients Patients in whom hand or forearm veins will not be accessible Uncontrolled hypertensives and diabetic patients Patients with history of dyspnoea or NYHA III or IV Patients with elevated serum creatinine Patient refusal Known history of allergy to propofol or Hydroxyethyl starch.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of pain on propofol injection	During induction with propofol-pain score wil be assessed every 15 secs till loss of verbal command

Secondary Outcome Measures

Name	Time	Method
Severity of pain on propofol injection using numerical rating scale	During induction with propofol-pain score wil be assessed every 15 secs till loss of verbal command

Trial Locations

Locations (1): Dayanand Medical College and Hospital
🇮🇳
Ludhiana, PUNJAB, India
Dayanand Medical College and Hospital
🇮🇳Ludhiana, PUNJAB, India
Dr Gurpreeti Kaur
Principal investigator
9779552017
grewal.preeti@gmail.com