Exposure to Air Pollutants and Green Space: Implications for the Gut Microbiome and Metabolome in Young Adults Living in Denver, Colorado
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Body mass index (BMI)
研究概览
简要总结
This study evaluates the associations between exposure to air pollutants, green space, and the gut microbiome and metabolome.
详细描述
A rapidly evolving field of study suggests a link between the gut microbiome and fecal metabolome with obesity. Recent studies show that environmental exposures, such as ambient air pollution (AAP) exposure can affect gut bacteria and modify risk for obesity. Additionally, proximity to green space has been shown to reduce exposure to air pollutants and increase gut microbial diversity. The investigator's preliminary work has shown that near-roadway air pollution exposure was positively correlated with gut microbial taxa that have been linked with obesity. These findings suggest that air pollution exposure may increase susceptibility to obesity through alterations in the composition and function of the gut microbiome. Despite this, no studies have systematically examined the impact of air pollutants and green space on the gut microbiome and metabolome among adolescents. The overall goal of this research is to determine whether exposure to air pollutants and/or green space affect the gut microbiome and metabolome in young adults residing in Denver, Colorado. This study will examine residential-based estimates of air pollution exposure and green space and also perform detailed gut microbial and metabolite profiling in 100 adolescent and young adults.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The participant population includes young adults (18-25 years of age) who live in Denver, Colorado.
排除标准
- •Exclusion criteria include physical, mental, or cognitive disability that prevents participation
- •Current incarceration
- •Antibiotic usage in the previous month
- •Pregnant or nursing
- •Non-English speaking
- •Any medical conditions known to affect body composition, insulin secretion, or the gut microbiota (i.e., type 1 or 2 diabetes, intestinal bowel disease, Crohn's Disease, kidney disease, heart disease, autoimmune disease).
结局指标
主要结局
Body mass index (BMI)
时间窗: Measured once at baseline visit date
Weight and height will be combined to report BMI in kg/m\^2
Gut Microbiome
时间窗: Measured once at baseline visit date
16S rRNA and Shotgun Sequencing
Fecal Metabolome
时间窗: Measured once at baseline visit date
Targeted and/or Un-targeted Metabolomics
Body Composition
时间窗: Measured once at baseline visit date
Waist and hip measurements will be taken
次要结局
- Physical Activity(Measured once at baseline)
- Fasting Insulin(Measured once at baseline)
- Air Pollution(One year before baseline visit date)
- Green Space(One year before baseline visit date)
- Serum Metabolome(Measured once at baseline visit date)
- Diet(Measured once at baseline)
- Fasting Glucose(Measured once at baseline)
研究者
Tanya Alderete
Assistant Professor
University of Colorado, Boulder