Breaking Sitting and Metabolic Health in Sedentary Overweight and Obese Adults
- Conditions
- Gut HormonesEnergy BalanceMetabolic Health
- Interventions
- Behavioral: Breaking sittingBehavioral: Prolonged sitting
- Registration Number
- NCT05306678
- Lead Sponsor
- National Taiwan Normal University
- Brief Summary
The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary overweight and obese adults.
- Detailed Description
Two trials are included in this project - Prolonged sitting and Breaking sitting.
In the Prolonged sitting trial, after consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min. In the Breaking sitting trial, after consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min. Blood samples were collected in a regular pattern throughout the trials. Energy balance (e.g., energy intake and spontaneous physical activity) was assessed using food diary and an accelerometer until midnight in the trial days once participants left laboratory.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
- Physical inactive males and females
- Aged between 20 and 45 years
- Overweight and obese healthy adults (waist circumference greater than 90 cm for males and 80 cm for females)
- Weight stable for more than 3 months (no change in weight +/- 3%)
- Non-smoker
- Able to walk comfortably on a treadmill
- Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
- Waist circumference < 90 cm for male and < 80 cm for female
- Taking medications that may influence lipid or carbohydrate metabolism or immune system function
- Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Breaking sitting Breaking sitting Breaking prolonged sitting Prolonged sitting Prolonged sitting Prolonged sitting
- Primary Outcome Measures
Name Time Method Gut hormones responses 320 minutes Changes in blood gut hormones responses (e.g., GLP-1, PYY and GIP concentrations measured in pmol/L) between trials
- Secondary Outcome Measures
Name Time Method Lipid profile 320 minutes Changes in blood lipid profile (e.g., TAG and cholesterol, etc.) between trials
Visual analogue scale (VAS) 320 minutes Changes in VAS from 0-100 mm (e.g., appetite and mood, etc.) between trials
Computerized cognitive testing 320 minutes Changes in cognitive function (e.g., accuracy and reaction time) between trials
Physical activity level 600 minutes after leaving the labalotory Changes in physical activity level (e.g., using an accelerometer to record) after leaving the laboratory until midnight
Energy intake 600 minutes after leaving the labalotory Changes in energy intake (e.g, using a food diary to record) after leaving the laboratory until midnight
Incremental area under curve (iAUC) for metabolic health 320 minutes Changes in incremental area under curve (iAUC) for insulin and glucose between trials
Blood pressure 320 minutes Changes in blood pressure (e.g., diastolic and systolic blood pressure) between trials
Trial Locations
- Locations (1)
National Taiwan Normal University
🇨🇳Taipei, Taiwan