Anticariogenic Effect of Sambucus williamsii var. coreana NAKAI (S. williamsii) Extract on Oral Disease Bacteria

Not Applicable

Completed

• Conditions: Not Applicable

• Registration Number: KCT0007064
• Lead Sponsor: Shilla University

Brief Summary

Application of mouthwash containing oo extract significantly decreased clinical values in all indicators of oral microbes, O’Leary index, PI, and GI (p<0.05). In addition, after gargling with a mouthwash containing , the antibacterial action on Gram-negative and Gram-positive bacteria that cause oral disease showed an excellent clinical effect in inhibiting, preventing, and treating oral diseases. The use of the mouthwash containing Sambucus williamsii var. coreana extract was found to be effective for oral desease related indicators and bacteria causing oral disease. Therefore, using a mouthwash containing Sambucus williamsii var. coreana extract, a natural drug, will possibly maintain healthy oral health by inhibiting and preventing the progression of oral disease.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-09-30
• Last Update Posted: 4 April 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

Participants in this study were healthy individuals without systemic disease among patients who agreed to fill out the questionnaire.

Exclusion Criteria

Among the study subjects, those with severe dental disease (e.g., periodontitis, dental caries, dry mouth, etc.) (patients with enamel caries among dental caries are eligible to participate in the study, with the exception of patients with more than one dentine caries), those who are undergoing treatment for general disease that may cause oral odor (e.g., hepatic disease, renal disease, Sjogren's syndrome, and rheumatism), those who smoke, those who have been diagnosed with sinusitis and/or rhinitis, those who are taking antibiotics, those with tongue problems (e.g., tongue cancer, glossitis, etc.), and those who received scaling within 2 months correspond to the exclusion criteria and were excluded from this study.

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mmicrobiological analysis

Secondary Outcome Measures

Name	Time	Method
O’Leary index ;Plaque index (PI) ;Gingival index (GI)