The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Not Applicable

Completed

• Conditions: Dental Caries
• Interventions: Other: Miswak; Other: Grape Seed Extract Mouthwash; Other: fluoride

• Registration Number: NCT04136639
• Lead Sponsor: Al-Azhar University

Brief Summary

Prevention of dental caries has taken a great importance in the last decade. The use of herbal and natural products became mandatory to avoid the side effects of commercially available medications. Aim of the study; the aim was to investigate the anti-cariogenic effect of miswak and grape seed extract (GSE).

Detailed Description

Patients used Miswak sticks, grape seed extract mouth wash and fluoride mouthwash twice daily for three month. Saliva samples were collected at base line and after one month and three month. Assessment of bacterial count and saliva buffering capacity were performed at base line and after one and three month.

Study Timeline

• Study Start: 2019-06-01
• Primary Completion: 2019-08-31
• Status Verified: 2019-10
• Study Completion: 2019-10-01
• Study First Submitted: 2019-10-19
• Study First Submitted QC: 2019-10-21
• Last Update Submitted: 2019-10-21
• Study First Posted: 2019-10-23
• Last Update Posted: 2019-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with high caries risk
• Males or females
• Medically free patients
• Patients approving to participate in the study

Exclusion Criteria

• Patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination
• Patients had history of professional cleaning in the last 15 days
• Patients with exposed pulp
• Evidence of parafunctional habits
• Patients with developmental dental anomalies
• Patients undergoing or will start orthodontic treatment
• Patients with removable prosthesis
• Periapical Abscess or Fistula

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Miswak	Miswak	Miswak sticks used twice daily, every 12 hours, for three months.
Grape Seed Extract	Grape Seed Extract Mouthwash	Grape seed extract 6.5% mouthwash used twice daily, every 12 hours, for three months.
Fluoride Mouthwash	fluoride	0.05% fluoride mouthwash used twice daily, every 12 hours, for three months.

Primary Outcome Measures

Name	Time	Method
quantitative measure of the change in salivary streptococcus mutans Count from baseline to one month and three months.	Baseline, one month, three months.	the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline,after one month and after three months. Every time samples were incubated with Mitiis Salivaris with Bacitricin and 20% sucrose for streptococcus mutans count.

Secondary Outcome Measures

Name	Time	Method
quantitative measure of the change in saliva buffering capacity from baseline to one month and three months.	baseline, one month , three months	the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline, after one month and after three months. each time, saliva buffering capacity was measured using Hand Held pH meter and 0.1 mol/l hydrochloric acid that was titrated to the tested saliva.

Trial Locations

Locations (1)

Al Azhar University; 🇪🇬 Cairo, Nasr City, Egypt