NCT04391920已完成不适用
Registry of CytoSorb Therapy in COVID-19 ICU Patients (CTC REGISTRY): Registry of Patient-level Clinical Data on CytoSorb Hemoadsorption Provided Via Integration of the CytoSorb Device Into Extracorporeal Membrane Oxygenation (ECMO), Continuous Renal Replacement Therapy (CRRT), or Hemoperfusion Extracorporeal Circuits in COVID-19 ICU Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 138
- 试验地点
- 7
- 主要终点
- ICU mortality
研究概览
简要总结
The CTC Registry collects patient-level clinical data on CytoSorb hemoadsorption provided to COVID-19 ICU patients via integration of the CytoSorb device into ECMO, CRRT, or hemoperfusion extracorporeal circuits. The intent of the registry is to gain understanding on how CytoSorb hemoadsorption provides clinical benefit to COVID-19 ICU patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed COVID-19
- •Provision of CytoSorb therapy per Instructions for Use (IFU) of the CytoSorb device.
排除标准
- •CytoSorb therapy for diseases other than COVID-19
- •Survival unlikely within 24 hours (for prospectively enrolled patients)
结局指标
主要结局
ICU mortality
时间窗: From the date of start of CytoSorb use until the date of ICU discharge or date of death, whichever comes first, assessed up to 1 year
次要结局
- Duration of mechanical ventilatory support after start of CytoSorb(From the date of start of CytoSorb use until the date of cessation of mechanical ventilatory support or date of death, which ever comes first, assessed up to 1 year)
- Change in serum concentrations of inflammatory biomarkers after start of CytoSorb(From the day before start of CytoSorb use until the day after cessation of CytoSorb use)
- Duration of pharmacologic hemodynamic support after start of CytoSorb(From the date of start of CytoSorb use until the date of cessation of pharmacologic hemodynamic support or date of death, which ever comes first, assessed up to 1 year)
- Change in Pa02/Fi02 ratio after start of CytoSorb(From the day before start of CytoSorb use until the day after cessation of CytoSorb use)
- Duration of ECMO after start of CytoSorb(From the date of start of CytoSorb use until the date of cessation of ECMO or date of death, which ever comes first, assessed up to 1 year)
研究者
研究点 (7)
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