To know which of the two drugs ketamine or dexamethasone are better in reducing sore throat in patients after undergoing surgery in complete unconsciousness if they are nebulized with either of the drugs before surgery.
Phase 1
- Conditions
- Health Condition 1: K35- Acute appendicitisHealth Condition 2: K80-K87- Disorders of gallbladder, biliary tract and pancreasHealth Condition 3: K55-K64- Other diseases of intestines
- Registration Number
- CTRI/2020/10/028497
- Lead Sponsor
- Vardhman Mahavir Medical College and Safdarjung Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients belonging to ASA Grade I and II, undergoing surgery of less than 2 hours duration in supine postion, under genral anaesthesia requiring orotracheal intubation
Exclusion Criteria
Patients with hsistory of sore throat or recent upper airway infection, respiratory disease, requiring oral or head and neck surgeries, pregnant females, patients with anticipated difficult airway (mallampatti class 3 and 4), allergy to any of the study drugs or on chronic medication (NSAIDS, Steroids)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the incidence of postoperative sore throat at 4h, in adult patients receiving preoperative ketamine nebulization or dexamethasone nebulization, undergoing general anaesthesia requiring endotracheal intubationTimepoint: 4 hours
- Secondary Outcome Measures
Name Time Method To assess postoperative cough and hoarseness if any.Timepoint: NIL;To assess the incidence of postoperative sore throat at 0, 2, 6, 12 and 24 h, in adult patients receiving preoperative keatmine nebulization or dexamethasone nebulization, undergoing general anaesthesia requiring endotracheal intubation.Timepoint: 0, 2, 6, 12, 24 hours;To assess the severity of postoperative sore throat at 0, 2, 4, 6, 12 and 24 hTimepoint: 0, 2, 4, 6, 12, 24 hours