Effect of droplet size of a fat emulsion, when given directly into the small intestinell intestinal on satiety and food intake in healthy volunteers.
Completed
- Conditions
- ObesityOvergewicht, obesitas
- Registration Number
- NL-OMON26271
- Lead Sponsor
- Jeroen MaljaarsDivision of Gastroenterology-Hepatology University Hospital Maastricht.PO Box 58002602 AZ MaastrichtThe NetherlandsEmail:PWJ.Maljaars@intmed.unimaas.nlTel: +31(0)433882983Fax: +31(0)433875006
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
1. Signed informed consent form
2. Sex: male or female
Exclusion Criteria
1. Evidence of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological/psychiatric diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess whether the fat droplet size in an emulsion affects satiety (as measured by visual analogue scales) and food intake (during ad libitum lunch) when infused into the duodenum and when infused into the ileum.
- Secondary Outcome Measures
Name Time Method To assess whether the fat droplet size in an emulsion affects gastric emptying, intestinal transit time and secretion of peptides known to affect satiety (CCK, PYY) when infused into the duodenum and when infused into the ileum.