The Prevalence and Genotype of Genital (High-Risk) Human Papillomavirus Infections in Female Renal Transplant Recipients

Recruiting

• Conditions: Cervico-vaginal HPV infection; Human papillomavirus infection of the cervix; 10016417

• Registration Number: NL-OMON35840
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 500

Inclusion Criteria

• Female sex
• Received a renal transplantation at the RUNMC in the period 1968 - 2008
• Age >= 18 years at start of the study

Exclusion Criteria

• Patients not willing to sign and/or return the informed consent form
• Patient is pregnant, or within a period of 3 months after delivery
• Patient is within a period of 3 months after miscarriage

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the prevalence of HPV infections and the<br /><br>distribution of different HPV genotypes in our immunocompromised cohort.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints are the prevalence of abnormal PAP smears and of cervical<br /><br>pathology as diagnosed by gynaecological examination and colposcopy.<br /><br><br /><br>Other study parameters:<br /><br>Population characteristics (sociodemographic features, medical data and<br /><br>information regarding sexual behaviour) and experiences of the self-sampling<br /><br>will be evaluated as well. Moreover, we will compare sociodemographic and<br /><br>medical data of the non-responders (i.e. age, marital status and duration of<br /><br>immunosuppression which will retrospectively be collected from the medical<br /><br>charts of these patients) with corresponding data of the responders.</p><br>