Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Respiratory acidosis
研究概览
简要总结
One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.
详细描述
The aim of the study is to:
- Evaluate whether the initial ventilation settings (tidal volume and respiratory rate) during one-lung ventilation are appropriate to prevent respiratory acidosis.
- Compare the ventilation settings (tidal volume and respiratory rate) made by clinicians with those proposed by an smartphone application ''VentilO''.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults (≥ 18 years old)
- •Patients intubated and undergoing one-lung ventilation during thoracic surgery
- •Volume-controlled ventilation mode used intraoperatively
排除标准
- •Arterial blood gas data unavailable during one-lung ventilation
- •Missing demographic data (sex, height, actual weight)
结局指标
主要结局
Respiratory acidosis
时间窗: 20 minutes after initiation of one lung ventilation after lung isolation
The frequency of respiratory acidosis on arterial blood gases after 20 minutes of mechanical ventilation (pH \< 7.35 and PaCO2 \> 45mmHg) measured by arterial blood gases
次要结局
- Mechanical Ventilation duration(Up to 90 days)
- Hospital length of stay(Up to 90 days)
- Acid-base disorder(At the beginning of one lung ventilation during the surgery)
- Respiratory rate(At the beginning of one lung ventilation during the surgery)
- Number of participants with hemodynamic shock - hypotension(Day 1)
- Hospital mortality(Up to 90 days)
研究者
François Lellouche
Principal Investigator
Laval University