Efficacy of high-flow nasal cannula compared with Conventional oxygen therapy In emergency participants with cardiogenic pulmonary edema: a randomized controlled study

Not Applicable

Completed

• Conditions: cardiogenic pulmonary edema diagnosed by - History of acute dyspnea- Bilateral rales on physical examination- Signs of pulmonary congestion shown on initial chest x- ray; cardiogenic pulmonary edema; High flow oxygen nasal cannula; Emergency department

• Registration Number: TCTR20150727001
• Lead Sponsor: Fisher&Paykel Healthcare Limited

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07-27
• Study Completion: 2016-03-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

1.Age > 18 years old
2.Diagnosed cardiogenic pulmonary edema
-History of acute dyspnea
-Bilateral rales on physical examination
-Signs of pulmonary congestion shown on initial chest x-ray
3.Pulse oximetry < 95% when breathing at room air, or 88% - 92% for hypercapnic participants
4.Respiratory rate (RR) > 24 times per minute

Exclusion Criteria

1.Participants who need immediate intubation
2.Participants with acute coronary syndrome
3.Participants with depressed level of consciousness (GCS<13)
4.Participants with hemodynamic compromise (Blood pressure < 90/60 mmHg)
5.Pregnant participants
6.Participants with respiratory failure; RR > 35 times per minute or SpO2 < 90% during or after having been given standard oxygen therapy for 10 minutes
7.Participants with CKD stage V or end-stage renal disease (ESRD)
8.Participants contraindicated for HFNC
9.Participants with concomitant pneumonia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
change in respiratory rate at 60 minutes physical examination

Secondary Outcome Measures

Name	Time	Method
change in SpO2 at 15, 30, 60 minutes pulse oximetry,change in heart rate and blood pressure at 15, 30, 60 minutes physical examination and spygmomanometer,Dyspnea score at 15, 30, 60 minutes Visual analog scale,Comfort score at 60 minutes Visual analog scale,change in CXR within 8 hours pulmonary edema score,Adverse event rate over study period monitor patients,Requirement for any escalation to intubation and/or NIV within 24 hours monitor patients,Hospital length of stay During length of stay Review hospital record,Mortality rate within 7 days Review hospital record and telephone call