Clinical Study of the Presence of Trichomonas Tenax and Entamoeba Gingivalis in Patients With Periodontitis

Completed

• Conditions: Periodontitis, Adult

• Registration Number: NCT03178838
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

The buccal cavity presents microorganismes whose the number and composition vary with oral hygiene and medical context (pathologies and associated drug therapies) of the patient. More than 1200 bacterial species have been identified, and among them, 400 are inhabitants of the sub-gingival biofilm. Among all these microorganismes, only 20 species participate to the etiopathogenesis of periodontal diseases.Some are recognised as major periodontopathogens other play unclear role in this pathology. They belong respectively to the red and orange complex of Socransky et al. (1998).

Other microorganismes such as virures, yeasts and protozoans could potentially impact the emergence and development of periodontal diseases. The presence of protozoans in periodontitis have been investigated in this study.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-12-03
• Primary Completion: 2014-11-11
• Study Completion: 2014-11-11
• Study First Submitted: 2017-06-06
• Study First Submitted QC: 2017-06-06
• Study First Posted: 2017-06-07
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-13
• Last Update Posted: 2017-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Adults > 18 years-old
• Consulting in periodontal department of CHU, Nancy
• Patient with moderate to severe periodontitis
• At least 2 periodontal sites with PPD≥ 4mm and One healthy site
• No scaling root planning in the last 6 months
• Patients insured under the French social security system

Exclusion Criteria

• Pregnant patients
• Patients with antibiotic therapy, and/or all medecines which could modify the buccal microbiota in the last 6 months
• Tooth with endodontic periapical lesion
• Patients having a scaling root planning in the last 6 months
• Patient with guardianship

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of protozoans	baseline

Secondary Outcome Measures

Name	Time	Method
Clinical attachment loss (mm)	baseline
Periodontal pocket depth (mm)	baseline
Plaque and gingival index	baseline
Presence of bleeding on probing (Yes/No)	baseline
Mobility of the tooth (Yes/No)	baseline