Reversibility of impaired cerebrovascular reactivity in patients with hypertension: comparison of losartan and atenolol

Not Applicable

Completed

• Conditions: Hypertension; Circulatory System

• Registration Number: ISRCTN77942127
• Lead Sponsor: niversity of Glasgow (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-27
• Last Update Posted: 7 November 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 13

Inclusion Criteria

1. Male: 50-80 years
2. Electrocardiogram (ECG) evidence of left ventricular hypertrophy (LVH)
3. Blood pressure (BP) 150-200/90-115

Exclusion Criteria

1. >70% internal carotid artery (ICA) stenosis
2. Middle cerebral artery (MCA) stenosis
3. Contra-indication to losartan, atenolol or acetazolamide
4. Serum creatinine >130 µmol/l
5. Prior treatment with angiotensin converting enzyme (ACE)-1/angiotensin II receptor blocker (ARB)/beta blocker unless able to stop 4 weeks prior to recruitment

Study & Design

• Study Type: Interventional
• Study Design: Not specified