Induction of tolerance through early introduction of peanut in high-risk childre
Completed
- Conditions
- Peanut allergy, peanut hypersensitivity, eczema, egg hypersensitivity, food hypersensitivityInjury, Occupational Diseases, PoisoningAllergy or hypersensitivity
- Registration Number
- ISRCTN94818122
- Lead Sponsor
- Immune Tolerance Network for National Institute of Allergy and Infectious Diseases
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 480
Inclusion Criteria
1. Children greater than four months and less than 11 months of age
2. Have had solid foods introduced successfully into their diet
3. Egg allergy, severe eczema or both
Exclusion Criteria
1. Clinically significant chronic illness, except for eczema or recurrent wheeze
2. Positive skin prick test for peanut allergen with a wheal diameter of greater than 4 mm
3. Previous or current consumption of peanut
4. Previous allergic reaction to peanut
5. Sibling or other household member who is allergic to peanut
6. Certain other immunological criteria
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The proportion of participants with peanut allergy at 60 months of age.
- Secondary Outcome Measures
Name Time Method 1. Effect of peanut consumption on other allergy outcomes<br>2. Safety of peanut consumption among study participants<br>3. Immunologic mechanisms by which consumption of peanut may induce tolerance to peanuts