Examining brain phenotypes in carriers of (common) mutations in Polymerase gamma (PolG) using 7T MRI imaging.

Recruiting

• Conditions: Brain structure; Mitochondrial disease; 10083624

• Registration Number: NL-OMON55367
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

-Carrier of a POLG mutation
-asymptomatic phenotype

Exclusion Criteria

-contra-indications for MRI
-severe phenotype

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Biomarkers in non-symptomatic POLG subjects, including anatomical and/or<br /><br>functional differences.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NVT</p><br>